Various computer-based simulation tools such as 3D-CAD and CAE systems are widely used to design automotive body structure at the early phase of design. Designers must search the optimal solution that satisfies a number of performance requirements by using their tools and a trial-and-error approach. In the previous three reports, a set-based design approach has been proposed for achieving design flexibility and robustness while capturing designer's preference, and its effectiveness has been illustrated with a simple side-door impact beam design problem and real vehicle side-door structure design. This report presents the development of integrated 3D-CAD and CAE system, and the applicability of our proposal for obtaining the multi-objective satisfactory design solutions by applying to an automotive front-side frame.