The design flexibility and robustness have become key factors to handle various sources of uncertainties at the early phase of design. Even though designers are uncertain about which single values to specify, they usually have a preference for certain values over others. In the first and second reports of a four-part paper, a set-based design approach has been proposed for achieving design flexibility and robustness while capturing designer's preference, and its effectiveness has been illustrated with a simple vehicle side-door impact beam design problem. This report presents the applicability of the proposed design approach to the large-scale multi-objective design optimization with a successful implementation of real vehicle side-door structure design.