The directions of the road are divided into two, the right-hand side and left-hand side of the road, by the convention and specific native method in the world. This paper deals with the characteristics and behaviors of drivers who are accustomed to driving on right-hand side of the road, drive with a handle on the left-hand side, and comparing with left-hand side drivers. The driver's eye movements were measured by eye camera and questionnaires were used for measuring subjective evaluation such as driving mental workload. The experimental results indicated even if the experts who had much experience on right-hand side driving, they had lower driving skill than novice driver, accustomed to driving on left-hand side. In terms of mental workload, MCH rating scale and MNASA-TLX, the right-hand side drivers were in lower stress condition than the left-hand side drivers because of having much driving experience. However, they conducted a few mistakes by confusing the position of turn signal and windshield wiper because of their driving habit or traits and it lead to operation mistakes. These results can be applied effectively to develop the driving support information with changed environments.