The objective of this study was to develop a model for safe work load based on a physiological model of metabolic energy of manual material handling tasks. Fifteen male subjects voluntarily participated in this study. Lifting activities with four different weights, 0, 8, 16, 24kg, and four different working frequencies (2, 5, 8, 11 lifts/min) for a lifting range from floor to the knuckle height of 76cm were considered. Oxygen consumption rates and heart rates were measured during the performance of sixteen different lifting activities. Simplified predictive equations for estimating the oxygen consumption rate and the heart rate were developed. The oxygen consumption rate and the heart rate could be expressed as a function of task variables; frequency and the weight of the load, and a personal variable, body weight, and their interactions. The coefficients of determination () of the model were 0.9777 and 0.9784, respectively, for the oxygen consumption rate and the heart rate. The model of oxygen consumption rate was modified to estimate the work load for the given oxygen consumption rate. The overall absolute percent errors of the validation of this equation for work load with the original data set was 39.03%. The overall absolute percent errors were much larger than this for the two models based on the US population. The models for the oxygen consumption rate and for the work load developed in this study work better than the two models based on the US population. However, without considering the biomechanical approach, the developed model for the work load and the two US models are not recommended to estimate the work loads for low frequent lifting activities.