Estimation of the process deviation is an important problem in statistical process control, especially in the control chart, process capability analysis or measurement system analysis. In this paper we suggest the use of the Gini's mean difference for the estimation of the c, the measure of the process deviation through a lots of simulations in various types of distributions. The Gini's mean difference uses the differences of all possible pairs of data. This point will improve the efficiency of estimation. In various classes of distributions, the Gini's mean difference shows good performance, in sense of bias of estimates or mean squared errors.