The purpose of this paper is to structure a new integrated model that can minimize the total cost for the transportation and inventory systems between m origin points, where origin i has a supply of a commodity, such as distribution centers or warehouses, and n destination points, where destination j requires the commodity. In this case, demands of the destination points are assumed random variables which have a known probability distribution. We will find optimal distribution centers which transport the commodity to the destination points and suggest optimal inventory policy to the selected distribution center which find the optimal pair $$ and safety stock level that minimize total cost with back-ordered case. This new model is formulated as a 0-1 nonlinear integer programming problem. To solve the problem, this paper proposes heuristic computational procedures and program and provides numerical examples.