This characteristics of process industries are high capital intensity, relatively long and sequence dependent setup times, and extremely limited capacity resources. The lot sizing, sequencing and limited capacity resources factors must he considered for production scheduling in these industries. This paper presents a mixed integer programming model for production scheduling. The economic trade offs between capacitated lot sizing flow shop scheduling and sequence dependent setup times also be compared with SMITH-DANIELS's model. As a results, it is shown that this paper has lower total cost, more efficient throughput than SMITH-DANIELS's model.